DNA methylation is a significant epigenetic alteration that is essential for controlling gene expression.

The majority of DNA methylation is observed on cytosines, which are followed by guanine residues (CpG). Cytosine methylated at the fifth carbon of the pyrimidine ring is known as 5-methylcytosine (5mC), and this kind of methylation is known as CpG methylation..

Research Area:

» DNA Methylation Analysis
» Targeted Bisulfite Sequencing
» Whole Genome Bisulfite Sequencing
» Methylation-Specific PCR
» DNA 5mC Quantification by LC-MS/MS
» DNA 5mC ELISA Quantification
» ChIP Sequencing (ChIP-Seq) Service

One significant epigenetic alteration that has an impact on gene expression is DNA methylation, which controls transcription. The study of cancer, postnatal development, embryonic development, and the impact of environmental hormones on epigenetic inheritance all make use of it.

Methylation Specific PCR is a technique for the detection of promoter hypermethylation at CpG islands in cell lines and clinical samples..

- DNA Extarction
- Sodium bisulfide modification of DNA
- DNA Extraction and recovery after modification
- Methylation specific PCR
- PCR data analysis

Toxicity and Genetics Genotoxicity describes the property of chemical agents that damages the genetic information within a cell causing mutations and dna methylation, which may lead to cancer .

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- Pharmaceuticals – for screening drug candidates
- Cancer Research
- Cosmetics – for in vitro toxicity testing
- Regenerative Medicine and Stem Cell Research
- Toxicology & Safety Testing
- Academic labs – outsourcing time-consuming culture work
- Biomanufacturing

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